Insulin Receptor Substrate-1 Deficiency Promotes Apoptosis in the Putative Intestinal Crypt Stem Cell Region, Limits Apc(min/+) Tumors, and Regulates Sox9

Reduced apoptosis of crypt stem/progenitor cells and elevated insulin and IGFs are linked to colon cancer risk. Insulin receptor substrate-1 (IRS-1) mediates the actions of insulin, IGF-I, and IGF-II, but the role of endogenous IRS-1 in crypt apoptosis and cancer is undefined. Using IRS-1(−/−), IRS-...

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Detalhes bibliográficos
Main Authors: Ramocki, Nicole M., Wilkins, Heather R., Magness, Scott T., Simmons, James G., Scull, Brooks P., Lee, Ginny H., McNaughton, Kirk K., Lund, P. Kay
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194604/
https://ncbi.nlm.nih.gov/pubmed/17916629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0869
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