Suppressor of Cytokine Signaling-2 Gene Disruption Promotes Apc(Min/+) Tumorigenesis and Activator Protein-1 Activation

Epigenetic in vitro and in vivo studies suggest that suppressor of cytokine signaling-2 (SOCS2) may normally limit tumorigenesis in the intestine; however, this theory has not been directly tested. We hypothesized that SOCS2 deficiency promotes spontaneous intestinal tumorigenesis in Apc(Min/+) mice...

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Detalhes bibliográficos
Main Authors: Newton, Victoria A., Ramocki, Nicole M., Scull, Brooks P., Simmons, James G., McNaughton, Kirk, Lund, P. Kay
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861097/
https://ncbi.nlm.nih.gov/pubmed/20348236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090684
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