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Comparison of Error Rates in Single-Arm Versus Randomized Phase II Cancer Clinical Trials

PURPOSE: To improve the understanding of the appropriate design of phase II oncology clinical trials, we compared error rates in single-arm, historically controlled and randomized, concurrently controlled designs. PATIENTS AND METHODS: We simulated error rates of both designs separately from individ...

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Hlavní autoři: Tang, Hui, Foster, Nathan R., Grothey, Axel, Ansell, Stephen M., Goldberg, Richard M., Sargent, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860370/
https://ncbi.nlm.nih.gov/pubmed/20212253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.5489
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