A novel norindeniosoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

We demonstrate that five topoisomerase I (Top 1) inhibitors (two indenoisoquinolines, two camptothecins, and one indolocarbazole) each intercalate between the base pairs flanking the cleavage site generated during the Top1 catalytic cycle and are further stabilized by a network of hydrogen bonds wit...

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Bibliographic Details
Main Authors: Marchand, Christophe, Antony, Smitha, Kohn, Kurt W., Cushman, Mark, Ioanoviciu, Alexandra, Staker, Bart L., Burgin, Alex B., Stewart, Lance, Pommier, Yves
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860177/
https://ncbi.nlm.nih.gov/pubmed/16505102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-05-0456
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