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Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34

Phosphoinositide 3-kinases (PI3Ks) have diverse and profound roles in health and disease. The primordial PI3K, Vps34, is present in all eukaryotes and has essential roles in autophagy, endosomal sorting, phagocytosis and signalling upstream of mTOR in nutrient sensing. The crystal structure of Vps34...

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Main Authors: Miller, Simon, Tavshanjian, Brandon, Oleksy, Arkadiusz, Perisic, Olga, Houseman, Benjamin T., Shokat, Kevan M., Williams, Roger L.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860105/
https://ncbi.nlm.nih.gov/pubmed/20339072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1184429
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