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ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase

Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino acid withdrawal, requires the ULK kinases. Despite its pivotal role in autophagy initiation, little is known about the mechanisms by which ULK promotes aut...

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Bibliografski detalji
Glavni autori: Russell, Ryan C., Tian, Ye, Yuan, Haixin, Park, Hyun Woo, Chang, Yu-Yun, Kim, Joungmok, Kim, Haerin, Neufeld, Thomas P., Dillin, Andrew, Guan, Kun-Liang
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885611/
https://ncbi.nlm.nih.gov/pubmed/23685627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2757
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