The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

The class III phosphatidylinositol 3-kinase (PI3KC3) plays a central role in autophagy. Rubicon, a RUN domain-containing protein, is newly identified as a PI3KC3 subunit through its association with Beclin 1. Rubicon serves as a negative regulator of PI3KC3 and autophagosome maturation. The molecula...

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Hlavní autoři: Sun, Qiming, Zhang, Jing, Fan, Weiliang, Wong, Kwun Ngok, Ding, Xiaojun, Chen, She, Zhong, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012973/
https://ncbi.nlm.nih.gov/pubmed/21062745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126425
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