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hVps15, but not Ca(2+)/CaM, is required for the activity and regulation of hVps34 in mammalian cells

The mammalian Class III PI3K (phosphoinositide 3-kinase), hVps34 [mammalian Vps (vacuolar protein sorting) 34 homologue], is an important regulator of vesicular trafficking, autophagy and nutrient sensing. In yeast, Vps34 is associated with a putative serine/threonine protein kinase, Vps15, which is...

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Bibliografske podrobnosti
Main Authors: Yan, Ying, Flinn, Rory J., Wu, Haiyan, Schnur, Rachel S., Backer, Jonathan M.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652830/
https://ncbi.nlm.nih.gov/pubmed/18957027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081865
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