Amino acids activate mTOR Complex1 via Ca(2+)/CaM signaling to hVps34

Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2 diabetes. Moreover, obesity and diabetes are contributing factors in the development of cancer, with recent studies suggesting this link is in part mediated by AA activation...

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Detalhes bibliográficos
Main Authors: Gulati, Pawan, Gaspers, Lawrence D., Dann, Stephen G., Joaquin, Manel, Nobukuni, Takahiro, Natt, Francois, Kozma, Sara C., Thomas, Andrew P., Thomas, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587347/
https://ncbi.nlm.nih.gov/pubmed/18460336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.03.002
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