Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino acid-driven mammalian target of rapamycin (mTOR) pathway to control the growth and development of the org...

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Bibliografiske detaljer
Main Authors: Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Dann, Stephen G., Kim, So Young, Gulati, Pawan, Byfield, Maya P., Backer, Jonathan M., Natt, Francois, Bos, Johannes L., Zwartkruis, Fried J. T., Thomas, George
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242323/
https://ncbi.nlm.nih.gov/pubmed/16176982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506925102
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