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mTOR activates the VPS34–UVRAG complex to regulate autolysosomal tubulation and cell survival
Lysosomes are essential organelles that function to degrade and recycle unwanted, damaged and toxic biological components. Lysosomes also act as signalling platforms in activating the nutrient-sensing kinase mTOR. mTOR regulates cellular growth, but it also helps to maintain lysosome identity by ini...
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| Veröffentlicht in: | EMBO J |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley & Sons, Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4585463/ https://ncbi.nlm.nih.gov/pubmed/26139536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201590992 |
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