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A poke in the eye: Inhibiting HIV-1 protease through its flap-recognition pocket

A novel mechanism of inhibiting HIV-1 protease (HIVp) is presented. Using computational solvent mapping to identify complementary interactions and the Multiple Protein Structure method to incorporate protein flexibility, we generated a receptor-based pharmacophore model of the flexible flap region o...

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Main Authors: Damm, Kelly L., Ung, Peter M. U., Quintero, Jerome J., Gestwicki, Jason E., Carlson, Heather A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859825/
https://ncbi.nlm.nih.gov/pubmed/18381626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.20993
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