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A poke in the eye: Inhibiting HIV-1 protease through its flap-recognition pocket
A novel mechanism of inhibiting HIV-1 protease (HIVp) is presented. Using computational solvent mapping to identify complementary interactions and the Multiple Protein Structure method to incorporate protein flexibility, we generated a receptor-based pharmacophore model of the flexible flap region o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859825/ https://ncbi.nlm.nih.gov/pubmed/18381626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.20993 |
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