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Clarifying Allosteric Control of Flap Conformations in the 1TW7 Crystal Structure of HIV-1 Protease
The 1TW7 crystal structure of HIV-1 protease shows the flaps placed wider and more open than what is seen in other examples of the semi-open, apo form. It has been proposed that this might be experimental evidence of allosteric control, because crystal packing creates contacts to the “elbow region”...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635929/ https://ncbi.nlm.nih.gov/pubmed/18704936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22195 |
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