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Binding to the Open Conformation of HIV-1 Protease: Binding the Open HIVp Flaps
A recent crystal structure of HIV-1 protease (HIVp) was the first to experimentally observe a ligand targeting an open-flap conformation. Researchers studying a symmetric pyrrolidine inhibitor found that two ligands co-crystallized with the protease, forcing an unusual configuration and unique cryst...
Bewaard in:
| Hoofdauteurs: | , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124008/ https://ncbi.nlm.nih.gov/pubmed/21604303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23054 |
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