Allosteric Communication between cAMP Binding Sites in the RI Subunit of Protein Kinase A Revealed by NMR

The activation of protein kinase A involves the synergistic binding of cAMP to two cAMP binding sites on the inhibitory R subunit, causing release of the C subunit, which subsequently can carry out catalysis. We used NMR to structurally characterize in solution the RIα-(98–381) subunit, a construct...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Byeon, In-Ja L., Dao, Khanh K., Jung, Jinwon, Keen, Jeffrey, Leiros, Ingar, Døskeland, Stein O., Martinez, Aurora, Gronenborn, Angela M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859567/
https://ncbi.nlm.nih.gov/pubmed/20197278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106666
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker