The Regulatory Subunit of PKA-I Remains Partially Structured and Undergoes β-Aggregation upon Thermal Denaturation

BACKGROUND: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of...

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Detalhes bibliográficos
Main Authors: Dao, Khanh K., Pey, Angel L., Gjerde, Anja Underhaug, Teigen, Knut, Byeon, In-Ja L., Døskeland, Stein O., Gronenborn, Angela M., Martinez, Aurora
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048872/
https://ncbi.nlm.nih.gov/pubmed/21394209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017602
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