Allosteric Communication between cAMP Binding Sites in the RI Subunit of Protein Kinase A Revealed by NMR

The activation of protein kinase A involves the synergistic binding of cAMP to two cAMP binding sites on the inhibitory R subunit, causing release of the C subunit, which subsequently can carry out catalysis. We used NMR to structurally characterize in solution the RIα-(98–381) subunit, a construct...

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Detalhes bibliográficos
Main Authors: Byeon, In-Ja L., Dao, Khanh K., Jung, Jinwon, Keen, Jeffrey, Leiros, Ingar, Døskeland, Stein O., Martinez, Aurora, Gronenborn, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859567/
https://ncbi.nlm.nih.gov/pubmed/20197278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106666
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