Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit

The ubiquitous second messenger cAMP mediates signal transduction processes in the malarial parasite that regulate host erythrocyte invasion and the proliferation of merozoites. In Plasmodium falciparum, the central receptor for cAMP is the single regulatory subunit (R) of protein kinase A (PKA). To...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Littler, Dene R., Bullen, Hayley E., Harvey, Katherine L., Beddoe, Travis, Crabb, Brendan S., Rossjohn, Jamie, Gilson, Paul R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207240/
https://ncbi.nlm.nih.gov/pubmed/27738107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750174
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