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Structural Basis for Differential Binding of the Interleukin-8 Monomer and Dimer to the CXCR1 N-Domain: Role of Coupled Interactions and Dynamics

Interleukin-8 (IL-8 or CXCL8) plays a critical role in orchestrating the immune response by binding and activating the receptor CXCR1 that belongs to the GPCR class. IL-8 exists as both monomers and dimers, and both bind CXCR1 but with differential affinities. It is well established that the monomer...

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Detalhes bibliográficos
Main Authors: Ravindran, Aishwarya, Joseph, Prem Raj B., Rajarathnam, Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858980/
https://ncbi.nlm.nih.gov/pubmed/19681642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901194p
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