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c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage
Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4(+)CD8(+) double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements,...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857587/ https://ncbi.nlm.nih.gov/pubmed/20383148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1865 |
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