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The Ras/MAPK Pathway Is Required for Generation of iNKT Cells
iNKT cells derive from CD4(+)CD8(+) DP thymocytes, and are selected by thymocyte-thymocyte interactions through signals from their invariant Vα14-Jα18 TCR and from the costimulatory molecules SLAMF1 and SLAMF6. Genetic studies have demonstrated the contribution of different signaling pathways to thi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091886/ https://ncbi.nlm.nih.gov/pubmed/21572967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019890 |
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