The Ras/MAPK Pathway Is Required for Generation of iNKT Cells

iNKT cells derive from CD4(+)CD8(+) DP thymocytes, and are selected by thymocyte-thymocyte interactions through signals from their invariant Vα14-Jα18 TCR and from the costimulatory molecules SLAMF1 and SLAMF6. Genetic studies have demonstrated the contribution of different signaling pathways to thi...

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Bibliografiske detaljer
Main Authors: Hu, Taishan, Gimferrer, Idoia, Simmons, Amie, Wiest, David, Alberola-Ila, José
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091886/
https://ncbi.nlm.nih.gov/pubmed/21572967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019890
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