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Covalent Cross-Linking of Glutathione and Carnosine to Proteins by 4-Oxo-2-nonenal

The lipid oxidation product 4-oxo-2-nonenal (ONE) derived from peroxidation of polyunsaturated fatty acids is a highly reactive protein cross-linking reagent. The major family of cross-links reflects conjugate addition of side-chain nucleophiles such as sulfhydryl or imidazole groups to the C=C of O...

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Hlavní autoři: Zhu, Xiaochun, Gallogly, Molly M., Mieyal, John J., Anderson, Vernon E., Sayre, Lawrence M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857574/
https://ncbi.nlm.nih.gov/pubmed/19480392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx9000144
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