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Charge Derivatized Amino Acids Facilitate Model Studies on Protein Side-Chain Modifications by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
The α-amino groups of histidine and lysine were derivatized with p-carboxylbenzyltriphenylphosphonium to form the pseudo dipeptides, PHis and PLys, which can be sensitively detected by MALDITOF mass spectrometry due to the fixed positive charge of the phosphonium group. Detection limits of PHis and...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902170/ https://ncbi.nlm.nih.gov/pubmed/19517464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rcm.4116 |
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