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Unravelling the mechanism of dual-specificity GAPs

The molecular mechanism by which dual-specificity RasGAPs of the Gap1 subfamily activate the GTP hydrolysis of both Rap and Ras is an unresolved phenomenon. RasGAPs and RapGAPs use different strategies to stimulate the GTPase reaction of their cognate G-proteins. RasGAPs contribute an arginine finge...

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Autores principales: Sot, Begoña, Kötting, Carsten, Deaconescu, Delia, Suveyzdis, Yan, Gerwert, Klaus, Wittinghofer, Alfred
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857463/
https://ncbi.nlm.nih.gov/pubmed/20186121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.20
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