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Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes

Rasal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGAP/RapGAP specificity, is epigenetically silenced in several tumor types. Surprisingly, the isolated protein has GAP activity on Rap but not on Ras. Its membrane recruitment is regulated by interaction w...

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Detalhes bibliográficos
Main Authors: Sot, Begoña, Behrmann, Elmar, Raunser, Stefan, Wittinghofer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538246/
https://ncbi.nlm.nih.gov/pubmed/23251034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201658110
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