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A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein

The hydrolysis of nucleoside triphosphates by enzymes is used as a regulation mechanism in key biological processes. Here, the GTP hydrolysis of the protein complex of Ras with its GTPase-activating protein is monitored at atomic resolution in a noncrystalline state by time-resolved FTIR spectroscop...

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Autori principali: Kötting, Carsten, Blessenohl, Marco, Suveyzdis, Yan, Goody, Roger S., Wittinghofer, Alfred, Gerwert, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599887/
https://ncbi.nlm.nih.gov/pubmed/16968776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604128103
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