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The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

Members of the Ras superfamily of small G proteins play key roles in signal transduction pathways, which they control by GTP hydrolysis. They are regulated by GTPase activating proteins (GAPs). Mutations that prevent hydrolysis cause severe diseases including cancer. A highly conserved “arginine fin...

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Detalles Bibliográficos
Main Authors: Kötting, Carsten, Kallenbach, Angela, Suveyzdis, Yan, Wittinghofer, Alfred, Gerwert, Klaus
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359817/
https://ncbi.nlm.nih.gov/pubmed/18434546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712095105
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