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The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

Members of the Ras superfamily of small G proteins play key roles in signal transduction pathways, which they control by GTP hydrolysis. They are regulated by GTPase activating proteins (GAPs). Mutations that prevent hydrolysis cause severe diseases including cancer. A highly conserved “arginine fin...

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Detalhes bibliográficos
Main Authors: Kötting, Carsten, Kallenbach, Angela, Suveyzdis, Yan, Wittinghofer, Alfred, Gerwert, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359817/
https://ncbi.nlm.nih.gov/pubmed/18434546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712095105
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