G-protein-coupled Receptor Kinase 5 Phosphorylates p53 and Inhibits DNA Damage-induced Apoptosis

G-protein-coupled receptor kinases (GRKs) are an important family of Ser/Thr kinases that specifically phosphorylate and desensitize the activated receptor in response to environmental stimulation. Here we identify p53, a key tumor suppressor, as a novel GRK substrate in vivo, revealing a previously...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Xiaoqing, Zhu, Huiling, Yuan, Man, Fu, Jie, Zhou, Yuqing, Ma, Lan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857122/
https://ncbi.nlm.nih.gov/pubmed/20124405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094243
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