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Processing of Meiotic DNA Double Strand Breaks Requires Cyclin-dependent Kinase and Multiple Nucleases

Meiotic recombination requires the formation of programmed Spo11-dependent DNA double strand breaks (DSBs). In Saccharomyces cerevisiae, the Sae2 protein and the Mre11-Rad50-Xrs2 complex are necessary to remove the covalently attached Spo11 protein from the DNA ends, which are then resected by so fa...

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Autores principales: Manfrini, Nicola, Guerini, Ilaria, Citterio, Andrea, Lucchini, Giovanna, Longhese, Maria Pia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857040/
https://ncbi.nlm.nih.gov/pubmed/20150422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104083
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