The Yku70–Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

DNA double-strand breaks (DSBs) are repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). HR requires 5′ DSB end degradation that occurs in the presence of cyclin-dependent kinase (CDK) activity. Here, we show that a lack of any of the NHEJ proteins Yku (Yku70–Yku80), Lif1...

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Main Authors: Clerici, Michela, Mantiero, Davide, Guerini, Ilaria, Lucchini, Giovanna, Longhese, Maria Pia
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
Assuntos:
Scientific Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515202/
https://ncbi.nlm.nih.gov/pubmed/18600234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.121
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