Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

Emerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes indepe...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Manfrini, Nicola, Clerici, Michela, Wery, Maxime, Colombo, Chiara Vittoria, Descrimes, Marc, Morillon, Antonin, d'Adda di Fagagna, Fabrizio, Longhese, Maria Pia
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541074/
https://ncbi.nlm.nih.gov/pubmed/26231041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08942
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