Continued primer synthesis at stalled replication forks contributes to checkpoint activation

Stalled replication forks activate and are stabilized by the ATR (ataxia-telangiectasia mutated and Rad3 related)-mediated checkpoint, but ultimately, they must also recover from the arrest. Although primed single-stranded DNA (ssDNA) is sufficient for checkpoint activation, it is still unknown how...

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Main Authors: Van, Christopher, Yan, Shan, Michael, W. Matthew, Waga, Shou, Cimprich, Karlene A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856894/
https://ncbi.nlm.nih.gov/pubmed/20385778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909105
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