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Continued DNA Synthesis in Replication Checkpoint Mutants Leads to Fork Collapse
Hydroxyurea (HU) treatment activates the intra-S phase checkpoint proteins Cds1 and Mrc1 to prevent replication fork collapse. We found that prolonged DNA synthesis occurs in cds1Δ and mrc1Δ checkpoint mutants in the presence of HU and continues after release. This is coincident with increased DNA d...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510540/ https://ncbi.nlm.nih.gov/pubmed/23045396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01060-12 |
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