MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2

Mutations in leucine-rich repeat kinase 2 (LRRK2) are prevalent causes of late-onset Parkinson’s disease (PD). Here, we show that LRRK2 binds to mitogen-activated protein kinase (MAPK) kinases MKK3, 6, and 7, and that LRRK2 is able to phosphorylate MKK3, 6 and 7. Over-expression of LRRK2 and MKK6 in...

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Hauptverfasser: Hsu, Cindy H., Chan, Diane, Greggio, Elisa, Saha, Shamol, Guillily, Maria D., Ferree, Andrew, Raghavan, Kesav, Shen, Grace C., Segal, Lilach, Ryu, Hoon, Cookson, Mark R., Wolozin, Benjamin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856721/
https://ncbi.nlm.nih.gov/pubmed/20067578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06568.x
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