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c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway

The ability of thymocytes to assess T cell receptor (TCR) signaling strength and initiate the appropriate downstream response is crucial for determining their fate. We have previously shown that a c-Cbl RING finger mutant knock-in mouse, in which the E3 ubiquitin ligase activity of c-Cbl is inactiva...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Thien, Christine B. F., Dagger, Samantha A., Steer, James H., Koentgen, Frank, Jansen, Elisa S., Scott, Clare L., Langdon, Wallace Y.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856302/
https://ncbi.nlm.nih.gov/pubmed/20133944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094920
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