Strain-induced Proliferation Requires the Phosphatidylinositol 3-Kinase/AKT/Glycogen Synthase Kinase Pathway

The intestinal epithelium is repetitively deformed by shear, peristalsis, and villous motility. Such repetitive deformation stimulates the proliferation of intestinal epithelial cells on collagen or laminin substrates via ERK, but the upstream mediators of this effect are poorly understood. We hypot...

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Bibliographische Detailangaben
Hauptverfasser: Gayer, Christopher P., Chaturvedi, Lakshmi S., Wang, Shouye, Craig, David H., Flanigan, Thomas, Basson, Marc D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629112/
https://ncbi.nlm.nih.gov/pubmed/19047055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804576200
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