Cholesterol Inhibits M-type K(+) Channels via Protein Kinase C-dependent Phosphorylation in Sympathetic Neurons

M-type (KCNQ) potassium channels play an important role in regulating the action potential firing in neurons. Here, we investigated the effect of cholesterol on M current in superior cervical ganglion (SCG) sympathetic neurons, using the patch clamp technique. M current was inhibited in a dose-depen...

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Bibliographic Details
Main Authors: Lee, Seul-Yi, Choi, Hyun-Kyung, Kim, Seong-Tae, Chung, Sungkwon, Park, Myoung Kyu, Cho, Jung-Hwa, Ho, Won-Kyung, Cho, Hana
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856299/
https://ncbi.nlm.nih.gov/pubmed/20123983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048868
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