Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

A group of phosphoinositide 3-kinase (PI3K) inhibitors, such as 3-methyladenine (3-MA) and wortmannin, have been widely used as autophagy inhibitors based on their inhibitory effect on class III PI3K activity, which is known to be essential for induction of autophagy. In this study, we systematicall...

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Bibliographic Details
Main Authors: Wu, You-Tong, Tan, Hui-Ling, Shui, Guanghou, Bauvy, Chantal, Huang, Qing, Wenk, Markus R., Ong, Choon-Nam, Codogno, Patrice, Shen, Han-Ming
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856291/
https://ncbi.nlm.nih.gov/pubmed/20123989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080796
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