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Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of aut...

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Autors principals: Lorin, Séverine, Tol, Marc J., Bauvy, Chantal, Strijland, Anneke, Poüs, Christian, Verhoeven, Arthur J., Codogno, Patrice, Meijer, Alfred J.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672295/
https://ncbi.nlm.nih.gov/pubmed/23575388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.24083
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