Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

A group of phosphoinositide 3-kinase (PI3K) inhibitors, such as 3-methyladenine (3-MA) and wortmannin, have been widely used as autophagy inhibitors based on their inhibitory effect on class III PI3K activity, which is known to be essential for induction of autophagy. In this study, we systematicall...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wu, You-Tong, Tan, Hui-Ling, Shui, Guanghou, Bauvy, Chantal, Huang, Qing, Wenk, Markus R., Ong, Choon-Nam, Codogno, Patrice, Shen, Han-Ming
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2010
الموضوعات:
Cell Biology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856291/
https://ncbi.nlm.nih.gov/pubmed/20123989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080796
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