SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

Abrogation of p53 function occurs in almost all human cancers, with more than 50% of cancers harboring inactivating mutations in p53 itself. Mutation of p53 is indicative of highly aggressive cancers and poor prognosis. The vast majority of mutations in p53 occur in its core DNA binding domain (DBD)...

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Detalhes bibliográficos
Main Authors: Demma, Mark, Maxwell, Eugene, Ramos, Robert, Liang, Lianzhu, Li, Cheng, Hesk, David, Rossman, Randall, Mallams, Alan, Doll, Ronald, Liu, Ming, Seidel-Dugan, Cynthia, Bishop, W. Robert, Dasmahapatra, Bimalendu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856225/
https://ncbi.nlm.nih.gov/pubmed/20124408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083469
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