SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

Abrogation of p53 function occurs in almost all human cancers, with more than 50% of cancers harboring inactivating mutations in p53 itself. Mutation of p53 is indicative of highly aggressive cancers and poor prognosis. The vast majority of mutations in p53 occur in its core DNA binding domain (DBD)...

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Bibliografiset tiedot
Päätekijät: Demma, Mark, Maxwell, Eugene, Ramos, Robert, Liang, Lianzhu, Li, Cheng, Hesk, David, Rossman, Randall, Mallams, Alan, Doll, Ronald, Liu, Ming, Seidel-Dugan, Cynthia, Bishop, W. Robert, Dasmahapatra, Bimalendu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856225/
https://ncbi.nlm.nih.gov/pubmed/20124408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083469
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