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Long-Lived, High-Strength States of ICAM-1 Bonds to β(2) Integrin, II: Lifetimes of LFA-1 Bonds Under Force in Leukocyte Signaling
Using single-molecule force spectroscopy to probe ICAM-1 interactions with recombinant α(L)β(2) immobilized on microspheres and β(2) integrin on neutrophils, we quantified an impressive hierarchy of long-lived, high-strength states of the integrin bond, which start from basal levels with activation...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856185/ https://ncbi.nlm.nih.gov/pubmed/20409465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4316 |
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