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Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds
Binding of lymphocyte function-associated antigen-1 (LFA-1) to intercellular adhesion molecule-1 (ICAM-1) mediates leukocyte adhesion under force. Using a biomembrane force probe capable of measuring single bond interactions, we showed ICAM-1 binding to LFA-1 at different conformations, including th...
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Main Authors: | , , |
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格式: | Artigo |
語言: | Inglês |
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American Society for Biochemistry and Molecular Biology
2010
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975219/ https://ncbi.nlm.nih.gov/pubmed/20819952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155770 |
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