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Hexameric Helicase Deconstructed: Interplay of Conformational Changes and Substrate Coupling

Hexameric helicases are molecular motor proteins that utilize energy obtained from ATP hydrolysis to translocate along and/or unwind nucleic acids. In this study, we investigate the dynamic behavior of the Simian Virus 40 hexameric helicase bound to DNA by performing molecular dynamics simulations e...

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Detalles Bibliográficos
Main Authors: Yoshimoto, Kenji, Arora, Karunesh, Brooks, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856183/
https://ncbi.nlm.nih.gov/pubmed/20409463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4315
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