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A Bistable Switch Underlying B-Cell Differentiation and Its Disruption by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin

The differentiation of B cells into antibody-secreting plasma cells upon antigen stimulation, a crucial step in the humoral immune response, is disrupted by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Several key regulatory proteins in the B-cell transcriptional network have been identified, with tw...

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Auteurs principaux: Bhattacharya, Sudin, Conolly, Rory B., Kaminski, Norbert E., Thomas, Russell S., Andersen, Melvin E., Zhang, Qiang
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855357/
https://ncbi.nlm.nih.gov/pubmed/20123757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq035
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