Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

The entry of human immunodeficiency virus (HIV-1) into cells is initiated by binding of the gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger conformational changes in gp120 that allow the gp41 transmembrane envelope glycoprotein to mediate viral-cell membrane f...

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Bibliographische Detailangaben
Hauptverfasser: Finzi, Andrés, Xiang, Shi-Hua, Pacheco, Beatriz, Wang, Liping, Haight, Jessica, Kassa, Aemro, Danek, Brenda, Pancera, Marie, Kwong, Peter D., Sodroski, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854584/
https://ncbi.nlm.nih.gov/pubmed/20227370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.012
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