Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

Trisomy of human chromosome 21 (Hsa21) results in Down syndrome (DS), a disorder that affects many aspects of physiology, including hematopoiesis. DS children have greatly increased rates of acute lymphoblastic leukemia and acute megakaryoblastic leukemia (AMKL); DS newborns present with transient m...

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Autores principales: Alford, Kate A., Slender, Amy, Vanes, Lesley, Li, Zhe, Fisher, Elizabeth M. C., Nizetic, Dean, Orkin, Stuart H., Roberts, Irene, Tybulewicz, Victor L. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854435/
https://ncbi.nlm.nih.gov/pubmed/20154221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-227629
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