Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats

Recent studies have shown that the renal cytochrome P-450 metabolites of arachidonic acid: the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE), and the vasodilator epoxyeicosatrienoic acids (EETs) play an important role in the pathophysiology of angiotensin II (ANG II)-dependent forms of h...

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Autors principals: Čertíková Chábová, Věra, Walkowska, Agnieszka, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Kujal, Petr, Vernerová, Zdena, Vaňourková, Zdenka, Kopkan, Libor, Kramer, Herbert J., Falck, John R., Imig, John D., Hammock, Bruce D., Vaněčková, Ivana, Červenka, Luděk
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854172/
https://ncbi.nlm.nih.gov/pubmed/20050826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20090459
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